Mr. & Mrs. Sidney Drew were an American comedy team on stage and screen.

Sidney Drew, or Mr. Sidney Drew as he was usually billed, was an uncle of the Barrymore family of actors: Lionel, Ethel & John Barrymore. His origins have been the subject of much speculation. Sidney’s mother Mrs Louisa Drew said she adopted him not long after the death of her husband John Drew Sr in 1862. Researchers have speculated that Sidney was Mrs Drew’s biological child either from her late husband or from a love affair. It was noticed that she disappeared for some time to the country before returning to Philadelphia with baby Sidney. John Barrymore always said Sidney looked too much like Grandmother Louisa to be anyone else’s child.

Sidney had been a light hearted leading man along with his wife, Gladys Rankin, better known as Mrs. Sidney Drew. They entered films as a team with the old Kalem Company in 1911, but achieved greater success after their switch to Vitagraph in 1913. Rankin died later that year and Sidney Drew was briefly paired with Clara Kimball Young, with whom Drew starred in the two-reel melodrama satire Goodness Gracious; or, Movies as they Shouldn’t Be directed by Clara’s husband James Young.

He remarried to Lucile McVey, born in Sedalia, Missouri, a Vitagraph scriptwriter who briefly went under the name Jane Morrow.